Beste MIV-behandelingsopsies vir pasgeborenes

26 November 2020 | Health

Navorsers van die Universiteit Stellenbosch (US) is op soek na die veiligste en doeltreffendste behandeling vir babas met ’n hoё risiko om MIV op te doen.
“Babas met MIV maak ’n klein deel van die MIV-positiewe bevolking uit en min antiretrovirale middelformulerings en farmakokinetiese data is tans beskikbaar om optimale behandeling te help rig,” sê prof Adrie Bekker van die Departement Pediatrie en Kindergesondheid aan die US se Fakulteit Geneeskunde en Gesondheidswetenskappe (FGGW).
“Ons het betekenisvolle vordering op die gebied van MIV gemaak, maar daar is steeds ’n gaping wat betref optimale voorkoming en die behandeling van babas van ma’s met MIV.”
In hoё-inkomstelande word behandeling met ’n kombinasie van drie middels aanbeveel vir pasgeborenes met ’n hoё risiko vir MIV-besmetting, maar baie min antiretrovirale middels is in werklikheid goedgekeur vir gebruik onder pasgeborenes (wat as die eerste 28 dae van lewe gedefinieer word).
Dit is ook moeilik om die formulerings wat tans beskikbaar is, aan babas toe te dien – ma’s en versorgers moet ’n spuit gebruik om spesifieke volumes af te meet, wat boonop verander soos wat die baba gewig optel. Voorts bevat van die bestaande kombinasies hoё konsentrasies van alkohol en polipropileen-glikol, wat toksies kan wees as dit van geboorte af gebruik word.
Die nuwe VDK-formulering hoef nie in alkohol opgelos te word nie, omdat dit in die vorm van m poeier is wat met ’n klein hoeveelheid borsmelk gemeng word. Dit smaak voorts lekkerder en hoef nie in ’n yskas verkoel te word nie. As die doeltreffendheid van hierdie formulering bewys word, kan ’n baba met ’n hoё risiko dit vir 4-6 weke as MIV-profilakse ontvang, of in die geval van MIV-besmetting aanhou om dit te gebruik.
“Hierdie is die eerste keer dat ons ’n nuwe lopinavir/ritonavir-formulering van geboorte af sal bestudeer, asook die gebruik van abacavir van so ’n jong ouderdom af. Derhalwe sal die vasstelling van middelblootstelling om dosering te rig belangrik wees,” verduidelik Bekker.
“Hierdie middelkombinasie sal maklik van geboorte af toegedien kan word. Voorts sal dit minder middelwisselings later meebring, wat beteken dit sal minder verwarrend vir versorgers wees.”
Bekker en dr Tim Cressey van die Chiang Mai-universiteit in Thailand is die hoofnavorsers van die PETITE-studie, wat die evaluering behels van die farmakokinetika en veiligheid van ’n nuwe vaste-dosis kombinasie (VDK) 4-in-1-korrelformulering (abacavir/lamivudine/lopinavir/ritonavir) vir pasgeborenes wat aan MIV blootgestel is.
Die studie word aangedryf deur ’n hoёprioriteit-navorsingsgaping wat in 2018 deur die Wêreldgesondheidsorganisasie se Pediatriese Antiretrovirale Middeloptimaliseringsgroep (Pado) geïdentifiseer is.
“Ons het die studieprotokol sedertdien aan die Pado-groep voorgelê en sal die resultate bekend maak soos wat ons vorder. As hierdie studie as doeltreffend en veilig bewys kan word, het dit die potensiaal om globale beleid te help rig,” aldus Bekker.

Similar News

 

Get your negative results via SMS

38 minutes ago | Health

The health ministry announced that negative Coronavirus Covid-19 test results from the Namibia Institute of Pathology (NIP) would now be communicated to clients via SMS....

Convenient and cost-effective HIV care

1 day - 19 January 2021 | Health

January is often a time when people review their budgets, both personally and professionally. For government bodies, the financial year is drawing to a close,...

Christmas in quarantine

1 day - 19 January 2021 | Health

Windhoek • Maria KandjunguNo one sang. There were no cheers of “Happy new year!”. It was just “quiet and weird.”This is how 10-year-old Angel describes...

NamBTS needs your blood

1 day - 18 January 2021 | Health

Swakopmund • [email protected] Namibia Blood Transfusion Service (NamBTS) announced an extreme blood shortage at the end of 2020, and pleads with Namibians to donate blood....

Fighting cervical cancer together

5 days ago - 15 January 2021 | Health

Human papillomavirus (HPV) is the most common viral infection of the reproductive tract. Most sexually active women and men will be infected at some point...

Covid stats in the spotlight

5 days ago - 14 January 2021 | Health

As the number of Covid-19 cases continues to rise in Namibia, the US Embassy also continues to provide support to the Ministry of Health and...

Minor amendments to Covid-19 regulations

6 days ago - 13 January 2021 | Health

The measures announced on 23 December 2020 to control and prevent Covid-19 lapse at midnight tonight, with health minister Dr Kalumbi Shangula saying earlier today...

Another set of wheels for EMA

1 month - 23 November 2020 | Health

EMA Rescue Service recently received their second ambulance for Windhoek and that will serve the public and assist everyone in case of an emergency, no...

Hepatitis-E slows down

1 month - 23 November 2020 | Health

Windhoek • [email protected] new hepatitis-E fatalities have been reported in Namibia since 3 March, when the death toll stood at 65. The Covid-19 pandemic has...

Children face trifecta of threats amidst Covid

1 month - 23 November 2020 | Health

Windhoek • [email protected] for the direct consequence of the Covid-19 itself, children face interruption in essentialservices and increasing poverty and inequality.During the World Children’s Day...

Latest News

EU assistance for Nyae Nyae...

20th of January 14:38 | Environment

Since the launch of the EU Governance support grant in March 2020, the Nyae Nyae conservancy has been hit hard by Covid-19. Despite these challenges,...

Why is your home not...

20th of January 14:33 | Life Style

The property market is experiencing a boom of activity, particularly in the first-time buyers’ market. Yet, despite high levels of interest, many parts of the...

Shake a can for CAN

20th of January 14:24 | Society

On Thursday, 4 February, the Cancer Association of Namibia (CAN) joins their global family of organisations to commemorate World Cancer Day, while creating awareness on...

Get your negative results via...

38 minutes ago | Health

The health ministry announced that negative Coronavirus Covid-19 test results from the Namibia Institute of Pathology (NIP) would now be communicated to clients via SMS....

Local accountants welcome Act Proposal

23 hours ago | Business

The Namibia Institute of Professional Accountants (NIPA) welcomed proposed amendments to the Public Accountants’ and Auditors’ Board (PAAB) Act, saying it will improve accountability and...

Convenient and cost-effective HIV care

1 day - 19 January 2021 | Health

January is often a time when people review their budgets, both personally and professionally. For government bodies, the financial year is drawing to a close,...

How is the property market...

1 day - 19 January 2021 | Life Style

Homebuyers, sellers, or those simply curious about real estate can benefit from chatting with a qualified real estate expert.To get the most out of this...

Stay vigilant when using free...

1 day - 19 January 2021 | Opinion

Windhoek • Desery van WykAs people look for diversity in working spaces from their “work from home” routine, such as coffee shops, the use of...

Calls to stop illegal sand...

1 day - 19 January 2021 | Environment

The City of Windhoek (CoW) has promised to focus on illegal sand mining at Groot Aub, which residents say is partly to blame for flooding...

Load More